Perfil glicometabólico inicial em pacientes com síndrome coronariana aguda e síndrome metabólica
| Autor: | Antonio Carlos Carvalho, Francisco Antonio Helfenstein Fonseca, L Oliveira, Simone M. Fischer, Carlos Manoel de Castro Monteiro, Luiz Fernando Muniz Pinheiro, Maria Cristina de Oliveira Izar, T. Helfenstein, Sahana W. Barros, Andreza O. Santos |
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| Rok vydání: | 2009 |
| Předmět: |
Acute coronary syndrome
medicine.medical_specialty Glucose tolerance test endocrine system diseases medicine.diagnostic_test Unstable angina business.industry nutritional and metabolic diseases Type 2 diabetes medicine.disease Impaired glucose tolerance Insulin resistance Diabetes mellitus Internal medicine medicine Cardiology Metabolic syndrome Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Arquivos Brasileiros de Cardiologia. 92 |
| ISSN: | 0066-782X |
| Popis: | BACKGROUND Patients with metabolic syndrome (MetS) are at high coronary risk and beta-cell dysfunction or insulin resistance might predict an additional risk for early cardiovascular events. OBJECTIVE This study aimed to evaluate early glucometabolic alterations in patients with MetS, but without previously known type 2 diabetes, after acute coronary syndrome. METHODS A total of 114 patients were submitted to an oral glucose tolerance test (OGTT) 1-3 days after hospital discharge due to myocardial infarction or unstable angina. Based on the OGTT, we defined three groups of patients: normal glucose tolerance (NGT; n=26), impaired glucose tolerance (IGT; n=39), or diabetes (DM; n=49). The homeostasis model assessment (HOMA-IR) was used to measure insulin resistance; beta-cell responsiveness was assessed by the insulinogenic index at 30 min (DeltaI30/DeltaG30). RESULTS Based on the HOMA-IR, patients with DM were more insulin-resistant than those with NGT or IGT (p |
| Databáze: | OpenAIRE |
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