| Popis: |
Iron Deficiency Anaemia which is reduced red blood cells due to iron deficiency had been reported to be a major challenge among Chronic Kidney Disease patients. The cause of anaemia in these patients is multifactorial, ranging from the inability of the kidneys to excrete hepcidin to even the inability of the kidneys to produce erythropoietin. This study aimed at comparatively assessing IDA between CKD and APHS in Niger Delta. A total of 88 subjects were recruited, 55(62.50%) CKDP and 33(37.50%) Control subjects. Samples were collected and analysed for IDA Indicators such as Serum Hepcidin Levels using commercial DRG Hepcidin-25 kit and other Haematological Indices using Automation (Sysmex KX-21N Automated Haematology Analyzer), Leishman Staining Technique and Supravital Staining Technique; Questionnaire was also used to obtain some data, data obtained were analysed using SPSS version 21.The mean values for Serum Hepcidin, Haemoglobin(HB), Packed Cell Volume(PCV), Red Blood Cell count(RBC), Mean Cell Volume(MCV), Mean Cell Haemoglobin(MCH), Mean Cell Haemoglobin Concentration(MCHC), Reticulocyte count(Retics) and Red Cell Distribution Width(RDW) were 52.00ng/ml, 10.00 g/dL, 31.00%, 3.74×102/L, 78.84fL, 26.58pg, 31.79g/dL, 0.64%, and 14.94% respectively in the CKD patients while that for the APHS were 16.00ng/ml, 14.00g/dL, 42.00%, 4.69×1012/L, 89.37fL, 29.59pg, 33.00g/dL, 1.09% and 13.20% respectively. Statistical T-Test of significance revealed that Serum Hepcidin level was elevated significantly in CKD patients (52.00ng/ml) when compared with APHS(16.00ng/ml) t86= 6.54, p |
