ChemInform Abstract: Synthesis of Tetrahydropyridazino(1,2-a)(1,2,4)benzotriazin-6-one Derivatives. A Novel Heterocyclic System

Autor:	Charles A. Webster, Ray Partha Sarathi, Joan Buote, Michael J. Manning
Rok vydání:	2010
Předmět:	Hydroxylation chemistry.chemical_compound Derivative (finance) chemistry Stereochemistry Amino derivatives Intramolecular cyclization General Medicine Methylation Acetonide
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199334194
Popis:	Synthesis of pyridazino[1,2-a][1,2,4]benzotriazin-6-one derivatives involving reaction of either 1,2,3,6-tetra-hydropyridazine (9) or hexahydropyridazine 14 with 2-fluoro-5-nitrophenylisocyanate (5) to give, via intramolecular cyclization, 3a and 16 respectively is described. Compound 3a was converted to 18 via methylation and hydroxylation to give 20 followed by conversion to the acetonide derivative 18. Both 16 and 18 were reduced to the amino derivatives 17 and 19 respectively.
Databáze:	OpenAIRE
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