Influence of Mg2+ concentration, pH value and specimen parameter on the hemolytic property of biodegradable magnesium

Autor: Ying Chen, Changli Zhao, Hongju Wang, Jianan Li, Yang Song, Xiaonong Zhang, Shaoxiang Zhang
Rok vydání: 2011
Předmět:
Zdroj: Materials Science and Engineering: B. 176:1823-1826
ISSN: 0921-5107
Popis: In this study, we first evaluated the hemolytic rate of pure magnesium and MgZn alloy, and the experimental results indicated that both of these two materials showed severe hemolysis. Furthermore, a revised hemolysis test was designed to assess the impact of the Mg 2+ concentration and the pH value on the hemolytic rate of magnesium. It was found that a Mg 2+ concentration of 11.4 ppm in the normal saline extract with a pH value of 7.35 or 4.93 did not demonstrate any hemolysis. However, the extract with the same Mg 2+ concentration but a pH value of 12.01 or 2.48 could result in heavy hemolysis. In addition, compared to the pervious study, it was suggested that there should be a preferred choice between the mass and the surface area of the specimen that used in the hemolysis test according to its different medical applications.
Databáze: OpenAIRE