ChemInform Abstract: Synthesis and Structure-Activity Relationships of 7-(2-Aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori Agents

Autor:	Takeshi Kawakita, Yoshifumi Ikeda, Katsuhiro Yamamoto, F. Hirayama, A. Moriguchi, Mitsuharu Sano, Tsuyoshi Kuroda, Nobuhiro Sakurai, S. Uemori
Rok vydání:	2010
Předmět:	biology Chemistry General Medicine Helicobacter pylori bacterial infections and mycoses biology.organism_classification Gerbil Microbiology
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199851191
Popis:	A series of the titled compounds was synthesized and tested for anti- Helicobacter pylori activities. We discovered Y-34867 having the most potent activity against Helicobacter pylori among the quinolones tested along with high photostability. Furthermore, Y-34867 showed an excellent therapeutic effect in the experimental Helicobacter pylori infected Mongolian gerbil model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c87b8b32cf92c4872d6bc8d51805f116 https://doi.org/10.1002/chin.199851191 Zobrazit plný text záznamu Plný text