Equilibria of formation and dehydration of the carbinolamine intermediate in the reaction of benzaldehyde with hydrazine
| Autor: | M.S. Baymak, Petr Zuman |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Polarography Chemistry Organic Chemistry Inorganic chemistry Hydrazone Limiting medicine.disease Biochemistry Medicinal chemistry Acid dissociation constant Dissociation (chemistry) Benzaldehyde chemistry.chemical_compound Drug Discovery medicine Dehydration Equilibrium constant |
| Zdroj: | Tetrahedron. 63:5450-5454 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2007.04.034 |
| Popis: | Measurement of polarographic limiting currents at equilibria made it possible at pH 3–7 to simultaneously determine concentrations of benzaldehyde, of its hydrazone and of the carbinolamine derivative. The dependence of concentration of carbinolamine at equilibrium on pH indicated presence of its di-, mono-, and unprotonated forms. Acid dissociation constants of the formation (pKa1≈3.2) of the diprotonated form and of the dissociation of the monoprotonated form of carbinolamine (pKa2≈4.7) were estimated. The equilibrium constants of formation (K1) and dehydration (K2) of the carbinolamine intermediate were determined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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