Epidermal Growth Factor in Cutaneous Repair Processes
| Autor: | A. Bertani, Armanda Pugnaloni, A. Belligolli, C. Castaldini, M. G. Tucci, R. Castagnani, G. Ricotti, Graziella Biagini |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Skin repair
medicine.medical_specialty Pathology Repair processes integumentary system Polymers and Plastics business.industry 0206 medical engineering Bioengineering 02 engineering and technology 021001 nanoscience & nanotechnology 020601 biomedical engineering Cutaneous tissue Biomaterials Andrology Plastic surgery Epidermal growth factor Materials Chemistry Extracellular medicine 0210 nano-technology business hormones hormone substitutes and hormone antagonists Explant culture |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 7:65-81 |
| ISSN: | 1530-8030 0883-9115 |
| DOI: | 10.1177/088391159200700107 |
| Popis: | Donor areas on patients undergoing plastic surgery were treated with epidermal growth factor (EGF) to stimulate tissue regeneration. Mor phometric analyses showed that cutaneous explants, treated with EGF, pre sented a higher number of microvessels ( p < 0.01) and mesenchimal cells ( p < 0.01), than untreated areas, while EGF did not improve epidermal thick ening. By electron microscopy, better histoarchitectural maturation of cellular and extracellular dermal compartments was observed after EGF application. This work provides evidence that EGF does stimulate skin repair by promoting the formation of mature cutaneous tissue. |
| Databáze: | OpenAIRE |
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