AB0065 ASSOCIATION OF SERUM LEVELS OF NESFATIN-1 WITH RHEUMATOID ARTHRITIS ACTIVITY AND ANXIETY-DEPRESSIVE DISORDERS

Autor: J. Polyakova, L. Seewordova, E. Papichev, Y. Akhverdyan, T. Kvlividze, В. Zavodovsky
Rok vydání: 2022
Předmět:
Zdroj: Annals of the Rheumatic Diseases. 81:1166.1-1166
ISSN: 1468-2060
0003-4967
0869-2084
DOI: 10.1136/annrheumdis-2022-eular.1594
Popis: BackgroundRheumatoid arthritis (RA) is primarily associated with pain levels and limited function. Depressive disturbances and anxiety levels are not usually assessed, the focus is on the physical aspects of the disease. At the same time, patients with high disease activity often experience a decrease in body weight and lack of appetite, which is referred to as rheumatoid cachexia. Nesfatin-1 (NF-1), discovered as an anorexigenic protein. The participation of NF-1 in the regulation of eating behavior and reactions to emotional stress together with oxytocin, melatonin, serotonin, and histamine receptors has been proven. Elevated levels of NF-1 are detected in more severe forms of depression, correlating with the level of inflammation markers - C-reactive protein and interleukin-6. Recent work confirms an increase in NF-1 levels in RA, although its role in inflammation has not yet been clearly defined.ObjectivesTo determine the correlation of the level of NF-1 in the blood serum of patients with RA with the level of anxiety and depression.Methods110 patients with RA were examined. NF-1 level concentration was determined by indirect enzyme-linked immunosorbent assay (RaiBiotech, cat no. EIA-NESF). The PHQ-9 scale was used to assess the severity of depressive symptoms, and the GAD-7 scale was used to assess the severity of anxiety symptoms.ResultsMood disorders of varying severity were detected in 48% of patients with RA. The highest levels of NF-1 were found in patients with high RA activity according to DAS-28 and disease duration of more than 10 years. The level of anxiety was more correlated with the severity of the disease activity (r = 0.351; pConclusionIn our study depression and high levels of anxiety were found in 48% of patients with RA, which is consistent with well-known data (the prevalence of mood disorders in RA ranges from 30 to 75%). The severity of depression and anxiety correlates with the level of NF-1, the frequency of occurrence depends on the activity and duration of the disease.References[1]Aleksandrov A., Aleksandrova N. Peculiarities of interaction of chronic inflammation and depression in Rheumatoid arthritis. Annals of the Rheumatic Diseases. 2021. Т. 80. № S1. С. 1110.[2]Hofmann T, Weibert E, Ahnis A, Obbarius A, Elbelt U, Rose M, Klapp BF, Stengel A. Alterations of circulating NUCB2/nesfatin-1 during short term therapeutic improvement of anxiety in obese inpatients. Psychoneuroendocrinology. 2017 May;79:107-115. doi: 10.1016/j.psyneuen.2017.02.021[3]Kvlividze T, Zavodovsky B, Akhverdyan Y, Polyakova Y, Sivordova L, Yakovlev A. Serum nesfatin-1 as a marker of systemic inflammation in rheumatoid arthritis. Klin Lab Diagn 2019;64:53-6. doi: 10.18821/0869-2084-2019-64-1-53-56Disclosure of InterestsNone declared
Databáze: OpenAIRE
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