Hyposmia in progressive supranuclear palsy
| Autor: | David J. Burn, David R. Williams, Janice L. Holton, Huw R. Morris, Graham Hughes, Andrew J. Lees, Ann E. Kingsbury, Aviva Petrie, H Ayling, Alistair Church, Tamas Revesz, Laura Silveira-Moriyama |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Mini–Mental State Examination Parkinson's disease medicine.diagnostic_test Lewy body Neurological disorder medicine.disease Gastroenterology eye diseases Progressive supranuclear palsy Central nervous system disease Neurology Hyposmia Internal medicine medicine Neurology (clinical) medicine.symptom Psychology Psychiatry Frontotemporal dementia |
| Zdroj: | Movement Disorders. 25:570-577 |
| ISSN: | 0885-3185 |
| DOI: | 10.1002/mds.22688 |
| Popis: | Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP-P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP. |
| Databáze: | OpenAIRE |
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