Representation Analysis of miRNA in Urine Microvesicles and Cell-Free Urine in Prostate Diseases
| Autor: | E. Yu. Rykova, Yu. B. Yurchenko, Ivan D. Osipov, Olga E. Bryzgunova, O. A. Pashkovskaya, Pavel P. Laktionov, M. M. Zaripov, Ivan A. Zaporozhchenko, S. V. Yarmoschuk, A. A. Zheravin, E. A. Lekchnov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Prostate Diseases business.industry Urinary system Clinical Biochemistry Context (language use) Urine Hyperplasia medicine.disease Biochemistry Microvesicles 03 medical and health sciences Prostate cancer 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis microRNA medicine Cancer research Molecular Medicine business |
| Zdroj: | Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 12:156-163 |
| ISSN: | 1990-7516 1990-7508 |
| Popis: | Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesicles-associated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urinary extracellular vesicles and demonstrated diagnostic potential of their miRNAs. In this study, we have performed a comparative analysis of 84 miRNA in paired samples of urine microvesicles and urine supernatant from healthy men, patients with benign prostate hyperplasia, and prostate cancer patients using miRCURY LNA miRNA qPCR Panels. In all groups of patients, miRNA subsets characterized by different distribution between the urinary fractions have been found. In this context, two groups of miRNAs have been identified, which are involved in several signaling pathways including those associated with prostate cancer development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink