Gehäuftes Auftreten hypermotiler Funktionsstörungen des Ösophagus bei Patienten mit arterieller Hypertonie
| Autor: | Pfaffenbach B, S. Bock, D. Hagemann, Ch. Szymanski, Romuald J. Adamek |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Incidence (epidemiology) General Medicine Chest pain medicine.disease Gastroenterology Endoscopy Blood pressure medicine.anatomical_structure Esophageal motility disorder Internal medicine Angiography medicine medicine.symptom Abnormality Esophagus business |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 123:341-346 |
| ISSN: | 1439-4413 0012-0472 |
| Popis: | BACKGROUND AND OBJECTIVE: It has been noted in previous manometric examinations of the oesophagus in patients with chest pain that abnormal motility was often associated with arterial hypertension. A systematic study of this relationship was therefore undertaken. PATIENTS AND METHODS: In 40 patients with chest pain (18 women and 22 men, mean age 54.7 [24-70] years) and in 20 healthy volunteers (12 men, 8 women, mean age 50.8 [22-63] years) standardized oesophageal manometry and arterial blood pressure monitoring were performed over 24 hours. Coronary heart disease and gastrointestinal lesions had been excluded by angiography and endoscopy, respectively. RESULTS: 20 patients (group H) had hypertension (median 24-hour blood pressure > 135/85 mmHg), while 20 patients (group N) and the normal controls (group K) were normotensive. Oesophageal manometry data differed significantly between the three groups regarding distal pressure amplitude (in hPa [hectopascals]; group H: 62 hPa*,**, group N 44 hPa* and group K 36 hPa**; [*P < 0.0005]) and the proportion of simultaneous contractions (group H 23%, group N 22%**, group K 10%***; ***P < 0.001). The hypertensive patients had significantly more frequent motility abnormalities than normal controls (13/20 vs 4/20, P < 0.001); while normotensive patients had more frequent episodes of abnormal propulsion in the oesophagus (proportion of propulsive contractions in group H: 53%, in N: 44%, in K: 59%; P < 0.01). CONCLUSION: Oesophageal motility differed significantly in patients with chest pain from that in healthy controls. Patients with chest pain and hypertension more frequently had oesophageal hypermotility. This suggests a generalized abnormality of smooth muscle. |
| Databáze: | OpenAIRE |
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