| Autor: |
Jean-Pierre Vilardaga, Ted B. Usdin, Caroline Silve, John Thomas Potts, Jr., Robert A. Nissenson, T. John Martin, Harald Jueppner, Rebecca Hills, Tom Gardella, Peter A. Friedman, Michael Chorev, Alessandro Bisello |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
IUPHAR/BPS Guide to Pharmacology CITE. 2023 |
| ISSN: |
2633-1020 |
| Popis: |
The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [50]) are class B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1 receptor) is activated by precursor-derived peptides: PTH (84 amino acids), and PTHrP (141 amino-acids) and related peptides (PTH-(1-34), PTHrP-(1-36)). The parathyroid hormone 2 receptor (PTH2 receptor) is activated by the precursor-derived peptide TIP39 (39 amino acids). [125I]PTH may be used to label both PTH1 and PTH2 receptors. The structure of a long-active PTH analogue (LA-PTH, an hybrid of PTH-(1-13) and PTHrP-(14-36)) bound to the PTH1 receptor-Gs complex has been resolved by cryo-electron microscopy [148]. Another structure of a PTH-(1-34) analog bound to a thermostabilized inactive PTH1 receptor has been obtained with X-ray crytallography [35]. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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