Functionalization of DNA-Tagged Alkenes Enabled by Visible-Light-Induced C–H Activation of N-Aryl Tertiary Amines
| Autor: | Jinqiao Wan, Sen Gao, Wenbo Sun, Alex Shaginian, Guansai Liu, Jin Li, Rongfeng Wu, Tian Du |
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| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
DNA damage Aryl Organic Chemistry Halide Photoredox catalysis 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Molecule Surface modification Physical and Theoretical Chemistry DNA |
| Zdroj: | Organic Letters. 23:3486-3490 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A highly efficient approach to C(sp3)-C(sp3) bond construction via on-DNA photoredox catalysis between on-DNA alkenes and N-aryl tertiary amines was developed. The methodology demonstrated 55%-95% conversions without obvious DNA damage, as seen by qPCR tests. Furthermore, various functional groups, such as carboxylic acids, aldehydes, and aryl halides, that can be used to create library diversities were shown to be tolerant of the C-H activation conditions. |
| Databáze: | OpenAIRE |
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