Strain Characteristics and Antibiotic Susceptibility of Isolates of Neisseria Gonorrhoeae Causing Disseminated Gonococcal Infection in Australia
| Autor: | John W. Tapsall, T R Shultz, E A Phillips, B. Way, K. M. Withnall |
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| Rok vydání: | 1992 |
| Předmět: |
Serotype
030505 public health medicine.drug_class Strain (biology) Antibiotics Public Health Environmental and Occupational Health S distribution Dermatology Biology medicine.disease_cause Gonococcal infection Virology Microbiology 03 medical and health sciences 0302 clinical medicine Infectious Diseases medicine Neisseria gonorrhoeae Pharmacology (medical) 030212 general & internal medicine 0305 other medical science |
| Zdroj: | International Journal of STD & AIDS. 3:273-277 |
| ISSN: | 1758-1052 0956-4624 |
| Popis: | The auxotype (A) and serovar (S) distribution and antibiotic and serum sensitivity of 22 strains of Neisseria gonorrhoeae isolated from blood and joints were determined. With one exception, these strains from disseminated gonococcal infections (DGI) belonged to one of 4 serovars of the IA serogroup and were resistant to killing by normal human serum. The auxotype distribution of these Australian strains differed significantly from that reported elsewhere in that 17 of the 22 isolates were proline requirers, but none were of the AHU auxotype. This lack of the AHU auxotype in the DGI strains in Australia was explained by the virtual absence of AHU requirers in a sample of 1560 mucosal strains isolated in Sydney and Darwin from 1987 to 1990. The A/S distribution of these mucosal isolates also helped to account for the low (0.12) percentage of DGI strains in isolates examined by the Australian Gonococcal Surveillance Programme (AGSP) from 1981 to 1991, and the differences in the rates of DGI in Sydney (0.08%) and Darwin (0.87%). There was a relative lack of the IA serogroup strains which are mostly responsible for DGI in the mucosal isolates from Sydney (15% of all strains) but a higher proportion of these serovars (40%) in the Darwin sample. There were 46 cases of DGI in data from the AGSP, 29 of these being women. Seven of the cases diagnosed in Australia were infected with penicillinase-producing gonococci suggesting that antibiotics other than the penicillins should now be used for this condition in this region. |
| Databáze: | OpenAIRE |
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