173 Effects of Phosphodiesterase 5 Inhibitor on Pulmonary Vascular Reactivity in The Fetal Lamb
| Autor: | Laurent Storme, Philippe Deruelle, Eric Magnenant, Ghazwan Butrous, S Jaillard, A. Delelis, B. Larrue, Thameur Rakza |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
medicine.drug_mechanism_of_action Sildenafil Phosphodiesterase Vasodilation PDE5 drug design respiratory tract diseases Nitric oxide Vascular reactivity chemistry.chemical_compound Endocrinology chemistry Internal medicine Pediatrics Perinatology and Child Health Fetal lamb cardiovascular system medicine Phosphodiesterase 5 inhibitor |
| Zdroj: | Pediatric Research. 56:493-493 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-200409000-00196 |
| Popis: | Background: Nitric Oxide (NO) released by pulmonary vascular endothelium is a potent vasodilator related to increased cGMP content. Hydrolysis of cGMP is achieved predominantly by cGMP–specific phosphodiesterases (PDEs). Sildenafil (SILD) is a selective phosphodiesterase–5 (PDE–5) inhibitor. The purpose of the study was to assess the effects of sildenafil on pulmonary vascular circulation during the perinatal period. |
| Databáze: | OpenAIRE |
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