Antiviral Activity of DG-35-VIII, a Potent Inhibitor of the Protease of Human Immunodeficiency Virus

Autor: CJ Birch, Gilda Tachedjian, L Buchanan, David Tyssen, Damian Grobelny, Q Chen, K Sebire
Rok vydání: 1997
Předmět:
Zdroj: Antiviral Chemistry and Chemotherapy. 8:99-106
ISSN: 2040-2066
Popis: The protease of human immunodeficiency virus (HIV) is an important target for antiretroviral drug therapy. The synthesis and in vitro antiviral activity of a novel protease inhibitor, DG-35-VIII, which contains an hydroxyethylhydrazide core unit, is described. DG-35-VIII had potent activity against HIV-1 and related viruses (HIV-2 and simian immunodeficiency virus) in an acutely infected T lymphocyte line (MT-2) and was also active in cells chronically infected with HIV-1, where it inhibited processing of the Pr55gag and Pr160 gag-pal precursor proteins.
Databáze: OpenAIRE