Antiviral Activity of DG-35-VIII, a Potent Inhibitor of the Protease of Human Immunodeficiency Virus
| Autor: | CJ Birch, Gilda Tachedjian, L Buchanan, David Tyssen, Damian Grobelny, Q Chen, K Sebire |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Protease biology viruses medicine.medical_treatment 030106 microbiology General Medicine Simian immunodeficiency virus medicine.disease_cause 01 natural sciences Virology Virus In vitro 0104 chemical sciences NS2-3 protease 010404 medicinal & biomolecular chemistry 03 medical and health sciences Enzyme chemistry Enzyme inhibitor biology.protein medicine Protease inhibitor (pharmacology) |
| Zdroj: | Antiviral Chemistry and Chemotherapy. 8:99-106 |
| ISSN: | 2040-2066 |
| Popis: | The protease of human immunodeficiency virus (HIV) is an important target for antiretroviral drug therapy. The synthesis and in vitro antiviral activity of a novel protease inhibitor, DG-35-VIII, which contains an hydroxyethylhydrazide core unit, is described. DG-35-VIII had potent activity against HIV-1 and related viruses (HIV-2 and simian immunodeficiency virus) in an acutely infected T lymphocyte line (MT-2) and was also active in cells chronically infected with HIV-1, where it inhibited processing of the Pr55gag and Pr160 gag-pal precursor proteins. |
| Databáze: | OpenAIRE |
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