INHALATION DEVICES FOR TREATMENT OF ASTHMA; A COMPARISON 0F NEBUHALER AND ROTAHALER
| Autor: | J van der Laag, I M J Rosina-Angelista |
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| Rok vydání: | 1985 |
| Předmět: | |
| Zdroj: | Pediatric Research. 19:1098-1098 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198510000-00173 |
| Popis: | The use of a standard metered aerosol needs considerable skill and coordination, which is extremely difficult for children. To ensure satisfactory inhalation of drugs several devices have been developed to overcome this problem. A study to compare the clinical and bronchodilator effect of Terbutaline-sulphate administered via a nebuhaler (TN), with that of Salbutamol powder administered via a rotahaler (SR), was carried out in 10 boys with stable moderate asthma; age-range 8-13 years. The effects were measured by means of spirometry and clinical assessment in a double-blind randomized cross-over fashion. With both drugs cumulative dose-response curves were established. With intervals of 20 minutes 0.25 mg of TN or 0.2 mg of SR was administered up to a maximal dose of 1.0 mg of TN and 0.8 mg of SR. Lungfunctiontests (FVC, FEV1, MMEF, MEF 50%, MEF 75%, PEFR) were performed 15 minutes after each administration of drug. In all children significant bronchodilatation was seen after 0.5 mg of TN or 0.4 mg of SR. The maximal bronchodilator effect of SR was significantly larger than that of TN, as can be shown for MMEF, MEF 50% and MEF 75%; this could not be shown for FEV1 and PEFR. Clinically side-effects didnot occur. For at least 5 hours after the last dose bronchodilatation was seen as shown by hourly PEFR-measurements. Since a good bronchodilator effect was shown with the use of a nebuhaler we conclude it to be a good device for inhalationtherapy in children, clinically comparable to the rotahaler; in our group, however, better bronchodilator effect was achieved with the rotahaler. |
| Databáze: | OpenAIRE |
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