Studies on quinoline derivatives and related compounds. VI. A novel displacement reaction of 1-ethylquinolinium iodides with nucleophiles

Autor:	Takenari Nakagome, Hideo Agui
Rok vydání:	1979
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Displacement reactions Nucleophile Chemistry Reagent Organic Chemistry Quinoline Iodide Organic chemistry Single displacement reaction Alkaline hydrolysis
Zdroj:	Journal of Heterocyclic Chemistry. 16:1353-1360
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570160713
Popis:	The reaction of 4-amino- (3a) and 4-anilino-3-carbethoxy-1-ethyl-6,7-methylenedioxy-quinolinium iodide (3b) with nucleophilic reagents produced 7-substituted 4-amino-3-carboxy-1-ethyl-6-hydroxyquinolinium betaines (5b-d) and 7-substituted 1-ethyl-1,4-dihydro-6-hydroxy-4-phenylimino-3-quinolinecarboxylic acid (6b-d), respectively, which led to 7-substituted 1-ethyl-1,4-dihydro-6-hydroxy-4-oxo-3-quinolinecarboxylic acids (1b-d) by alkaline hydrolysis. With a variety of 1-ethyl-1,4-dihydroquinoline carboxylates (16a-e) these novel displacement reactions were attempted.
Databáze:	OpenAIRE
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