Epigenetic alteration of BDNF gene, social and health status as predictors of food and nutrition insecurity among familiar coffee farmers
| Autor: | Wagner Miranda Barbosa, Carlos César Jorden Almança, Flavia Vitorino Fretias, Catarine Conti, Julia De Assis Pinheiro, Alcemi Almeida de Barros, Joaquim Gasparini dos Santos, Aline Ribeiro Borçoi, João Batista Pavesi Simão, Luciane Daniele Cardoso, Juliana Krüger Arpini, Mayara Mota de Oliveira, Juliana Dalbó, Anderson Barros Archanjo, Suzanny Oliveira Mendes, Lucas De Lima Maia, Iúri Louro, Adriana Madeira Álvares-da-Silva |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Human Growth and Development. 32:227-236 |
| ISSN: | 2175-3598 0104-1282 |
| DOI: | 10.36311/jhgd.v32.13846 |
| Popis: | Introduction: state of Food and Nutritional Security (FNS) is one that should guarantee the right of permanent access to quality food and in sufficient quantity without prejudicing access to other basic rights. In Brazil, rural family farming establishments represent 84.4% of total agricultural establishments and contribute to more than 70% of all food consumed by Brazilians. In this context, the production of the coffee commodity stands out. However, despite being food producers, they do not earn a good income. Slow economic activity can lead to loss of wages and income, illness, as well as food insecurity (FNiS). In addition, the molecular effects of FNiS are poorly studied, especially epigenetic. Objective: the objective of the present study is to analyze the association between Brain-Derived Neurotrophic Factor (BDNF) DNA methylation and socio demographic, lifestyle, and epigenetic factors, among coffee farmers in the Caparaó zone, in Espirito Santo, Southeast Brazil. Methods: the study was carried out in 22 randomly selected coffee producing communities in Zona Caparaó, an area that produces coffee of recognized quality. A total of 570 coffee farming households, 18 to 60 years of age, were included in the study by answering a questionnaire about socioeconomic characteristics, land use and ownership, behavior, health, and working conditions. FNiS evaluation was carried out using the Brazilian Food Insecurity Scale. BDNF exon I methylation was examined by methylation-specific PCR. Body mass index and biochemical analyses were performed. Logistic regression models were used to verify factors associated with FNiS (p |
| Databáze: | OpenAIRE |
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