Comparative study of specific and non-specific interactions between bio-macromolecules and ligands

Autor:	Makoto Nishimoto, Hitoshi Matsuki, Ukyo Komatsu, Kenji Ogli, Shoji Kaneshina
Rok vydání:	2005
Předmět:	biology Ligand Bilayer General Medicine chemistry.chemical_compound Membrane chemistry Biochemistry Dipalmitoylphosphatidylcholine Anesthetic biology.protein medicine Luciferase Long chain fatty acid Bovine serum albumin medicine.drug
Zdroj:	International Congress Series. 1283:207-210
ISSN:	0531-5131
DOI:	10.1016/j.ics.2005.07.023
Popis:	Interactions between inhalation anesthetics and three kinds of bio-macromolecules, firefly luciferase (FFL), bovine serum albumin (BSA) and dipalmitoylphosphatidylcholine (DPPC) bilayer membrane were compared with the corresponding ones between long-chain fatty acids and the bio-macromolecules. The influence of the anesthetics on FFL and DPPC bilayer membrane antagonized against that of the fatty acids. On the contrary, the influences of both ligands on BSA synergized, however, that of the anesthetics was remarkably smaller than that of the fatty acids. The results are attributable to the difference in ligand receptivities, that is, molecular-recognition abilities of the bio-macromolecules. The present study showed the importance of non-specific interactions in anesthetic mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c8359156fbc4b7fb46dfcc2331152caf https://doi.org/10.1016/j.ics.2005.07.023 Zobrazit plný text záznamu Full Text from ScienceDirect