AB0508 RISK FACTORS FOR DEVELOPMENT OF ATHEROSCLEROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS

Autor: T. Panafidina, T. Popkova, L. Kondrateva, Y. Gorbunova, E. Nasonov
Rok vydání: 2022
Předmět:
Zdroj: Annals of the Rheumatic Diseases. 81:1381-1381
ISSN: 1468-2060
0003-4967
DOI: 10.1136/annrheumdis-2022-eular.2695
Popis: BackgroundSystemic lupus erythematosus (SLE) has been strongly linked to accelerated atherosclerosis and increased cardiovascular morbidity and mortality.ObjectivesThe goal is to evaluate the traditional cardiovascular risk factors (TRF), intima-media wall thickness (IMT) and cardiovascular events (CVE) in SLE patients as compared to the same-nationality populations.MethodsThis cross-sectional study included 227pts (69% females, aged 35,6±0,7years) with SLE according to SLICC/ACR 2012 criteria, attending a routine visit at our Clinic between February 2018 and February 2020. Carotid plaques were assessed by ultrasound (US). Disease duration was 132,9±7,7months, SLEDAI 2K–9,4±0,5, SLICC/DI–1,89±0,13 score. Briefly, 90% had a history of joint involvement, 72%-hematological involvement, 70%-nephritis, 67%-serositis, 64%-skin lesions, 48%-neuropsychiatric involvement.Out of them 82%pts were on prednisone therapy at 17,3±1,0mg/day, 41%–on HCQ, 22%-immunosuppressants. Forty-one (18%) patients were diagnosed with SLE for the first time and were not receiving therapy at the time of enrollment.Concomitant antiphospholipid syndrome (APS) had 24% of SLEpts: 80% of SLE+APSpts had venous thrombosis, 43%-arterial, 56%-obstetric pathology. The control group (healthy donors) was matched by age and gender (n=99, 79% females, aged 36,2±0,8years).ResultsPatients with SLE compared to controls had a higher incidence of hypertension (52% and 21%,pFollowing carotid US assessment, atherosclerotic plaques (IMT≥1,5 mm) occurred in 24% of SLEpts versus 5% of controls,pClinical manifestations of atherosclerosis (CVE) were reported in 19% of SLEpts vs 2% of controls, p0,05, stroke – 7% vs 1%, p>0,05. SLEpts had HR of CVE of 9,16 (95%CI 2,26-37,09), of CAD - 6,54 (95%CI 1,59-26,84).In SLEpts carotid plaques were more common than in controls at the age of 30-49 years, p50 years, pPatients were found to correlate CVE with age (r=0,384,pConclusionThe frequency of CVE (CAD, MI) and carotid plaques is higher in patients with SLE than in controls. In patients, CAD and carotid plaques were detected more frequently at the age of 30-49 years than in controls.Hypertension, hypertriglyceridemia and low HDL are the most common TRF in young SLE patients.In SLE, not only TRF and their number are associated with CVE, but also SLE duration, SLICC/DI, steroid use duration and cumulative dose.Disclosure of InterestsNone declared
Databáze: OpenAIRE
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