The Healthy Living Partnerships to Prevent Diabetes Study

Autor: Carolyn F. Pedley, David C. Goff, Jeffrey A. Katula, Caroline S. Blackwell, Scott Isom, Timothy M. Morgan, Mara Z. Vitolins, Michael S. Lawlor
Rok vydání: 2013
Předmět:
Zdroj: American Journal of Preventive Medicine. 44:S324-S332
ISSN: 0749-3797
DOI: 10.1016/j.amepre.2012.12.015
Popis: Background: Since the Diabetes Prevention Project (DPP) demonstrated that lifestyle weight-loss interventions can reduce the incidence of diabetes by 58%, several studies have translated the DPP methods to public healthfriendly contexts. Although these studies have demonstrated short-term effects, no study to date has examined the impact of a translated DPP intervention on blood glucose and adiposity beyond 12 months of follow-up. Purpose: To examine the impact of a 24-month, community-based diabetes prevention program on fasting blood glucose, insulin, insulin resistance as well as body weight, waist circumference, and BMI in the second year of follow-up. Design: An RCT comparing a 24-month lifestyle weight-loss program (LWL) to an enhanced usual care condition (UCC) in participants with prediabetes (fasting blood glucose95125 mg/dL). Data were collected in 20072011; analyses were conducted in 20112012. Setting/participants: 301 participants with prediabetes were randomized; 261 completed the study. The intervention was held in community-based sites. Intervention: The LWL program was led by community health workers and sought to induce 7% weight loss at 6 months that would be maintained over time through decreased caloric intake and increased physical activity. The UCC received two visits with a registered dietitian and a monthly newsletter. Main outcome measures: The main measures were fasting blood glucose, insulin, insulin resistance, body weight, waist circumference, and BMI. Results: Intent-to-treat analyses of between-group differences in the average of 18- and 24-month measures of outcomes (controlling for baseline values) revealed that the LWL participants experienced greater decreases in fasting glucose (4.35 mg/dL); insulin (3.01 U/ml); insulin resistance (0.97); body weight (4.19 kg); waist circumference (3.23 cm); and BMI (1.40), all p-values 0.01. Conclusions: A diabetes prevention program administered through an existing community-based
Databáze: OpenAIRE
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