Influence of Cross-Linking Agents on Apatite-forming Ability of Pectin Gels

Autor: Takashi Ichibouji, Koichi Kuramoto, Atsushi Sugino, Chikara Ohtsuki, Toshiki Miyazaki, Masahiro Ashizuka, Eiichi Ishida
Rok vydání: 2007
Předmět:
Zdroj: Key Engineering Materials. :559-562
ISSN: 1662-9795
DOI: 10.4028/www.scientific.net/kem.361-363.559
Popis: Natural bone is a kind of organic-inorganic hybrid composed of collagen and apatite crystals with a structure that provides specific mechanical properties such as high fracture toughness and flexibility. Materials exhibiting both high flexibility and bioactivity similar to natural bone are required for novel bone-repairing materials in medical fields. We expect that we can design such materials by mimicking the bone structure. Biomimetic process has been paid much attention where bone-like apatite is deposited on organic polymers in simulated body fluid (SBF). In this study, we investigated influence of cross-linking agents on apatite-forming ability of pectin gels. Pectin is a polysaccharide abundant in carboxyl group. Pectin gels were prepared by cross-linking of pectin aqueous solutions with calcium ions or divinylsulfone (DVS). Apatite-forming ability of the gels was examined in SBF. The citrus-derived pectin showed tendency to form the largest amount of the apatite independent on a kind of cross-linking agents in SBF.
Databáze: OpenAIRE