Synthesis of Photoreactive 2-Phenethylamine Derivatives - Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling

Autor:	Lei Wang, Yui Ogasawara, Yasuyuki Hashidoko, Yuta Murai, Makoto Hashimoto, Katsuyoshi Masuda, Yasumaru Hatanaka, So Iwata, Takuya Kobayashi
Rok vydání:	2013
Předmět:	Phenethylamine Photoaffinity labeling Functional analysis Stereochemistry Organic Chemistry Biological activity Adenosine receptor Adenosine chemistry.chemical_compound chemistry Biochemistry Phenyl azide Benzophenone medicine Physical and Theoretical Chemistry medicine.drug
Zdroj:	European Journal of Organic Chemistry. 2013:2428-2433
ISSN:	1434-193X
DOI:	10.1002/ejoc.201201657
Popis:	2-Phenylethylamine is well known as a substructure of many biologically active compounds, and the synthesis of its photoreactive derivatives to allow the analysis of biological functions is reported. This allowed us to synthesise ligands for adenosine receptors, which have many functional roles in biology and have been extensively studied for their many roles in maintaining homeostasis. Adenosine is one of the most common biochemical compounds, but photoaffinity labeling has not yet been used to study adenosine receptors. Synthetic methods for producing photoreactive adenosine derivatives that can be used with adenosine receptors were established for the photophores phenyl azide and benzophenone. The effect of the introduction of the photoreactive components was determined using an adenosine receptor assay.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c808f9168f48a7d0f69a18f77439fe20 https://doi.org/10.1002/ejoc.201201657 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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