ChemInform Abstract: Lithium Chloride-Assisted Selective Hydrolysis of Methyl Esters under Microwave Irradiation

Autor:	Ping Ying, Xiao-Ai Wu, Yue Chen, Heng-Shui Shen, Jun-Yang Liu, Ling He
Rok vydání:	2010
Předmět:	inorganic chemicals Chemistry Substituent chemistry.chemical_element General Medicine Catalysis Solvent chemistry.chemical_compound Hydrolysis Lithium chloride Reactivity (chemistry) Lithium Selectivity Nuclear chemistry
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
Popis:	A rapid and mild method for the selective hydrolysis of methyl ester in lithium chloride–N,N-dimethylformamide (LiCl–DMF) system under microwave irradiation has been developed. The effects of substituent, metal salt, and solvent on the reactivity and selectivity of the hydrolysis reaction have been investigated. Microwave irradiation significantly improves the reaction yield within a short time in an LiCl–DMF system. Moreover, the chiral α-carbon of methyl esters retained its configuration during the reaction. Finally, the catalytic mechanism of hydrolysis by LiCl salt has also been proposed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c808d127817eda01609595e6193cde9d https://doi.org/10.1002/chin.201014076 Zobrazit plný text záznamu Plný text