| Autor: |
Mongraw-Chaffin, Morgana L., Matsushita, Kunihiro, Brancati, Frederick L., Young, Jeffery Hunter, Crawford, Stephen O., Coresh, Josef, Hoogeveen, Ron C., Ballantyne, Christie M., Schmidt, Maria Inês, Astor, Brad C. |
| Jazyk: |
angličtina |
| Předmět: |
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| Popis: |
BackgroundThe objective of this study is to compare lactate levels between users and non-users of diabetes medications under the hypothesis that the level of lactate is a marker of oxidative capacity.MethodsThe cross-sectional data of 493 participants aged 61–84 with type 2 diabetes who participated in the Atherosclerosis Risk in Communities Carotid MRI study were analyzed using survey weighted linear regression.ResultsMedian plasma lactate level was 8.58 (95% CI: 8.23, 8.87) mg/dl. Comparing users of diabetic medications with non-users, thiazolidinedione use was significantly associated with lower lactate level (7.57 (6.95–8.25) mg/dL vs. 8.78 (8.43–9.14) mg/dL), metformin use with a slightly higher lactate level (9.02 (8.51–9.58) mg/dL vs. 8.36 (7.96–8.77) mg/dL), and sulfonylurea and insulin use were not associated with lactate level. After adjustment for demographic and lifestyle factors, the plasma lactate level for thiazolidinedione users was 15.78% lower than that for non-users (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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