Plasma microRNA-192 expression as a potential biomarker of diabetic kidney disease in patients with type 2 diabetes mellitus
| Autor: | Sameh A Lashen, Eman Tayae Elsayed, Eman Yousef Morsy, Shimaa Mohamed El-Rahmany, Talaat Abd El Fattah Abdelaty |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Creatinine endocrine system diseases business.industry Endocrinology Diabetes and Metabolism nutritional and metabolic diseases Type 2 Diabetes Mellitus Disease medicine.disease Gastroenterology chemistry.chemical_compound chemistry Internal medicine Diabetes mellitus Potential biomarkers microRNA Internal Medicine medicine Albuminuria Outpatient clinic medicine.symptom business |
| Zdroj: | Clinical Diabetology. 9:454-460 |
| ISSN: | 2450-8187 2450-7458 |
| Popis: | Background. Albuminuria is an early clinical indicator of diabetic kidney disease (DKD). However, it has several limitations. The aim of this study was to evaluate the plasma microRNA-192 (miRNA-192) expression and its diagnostic performance in patients with type 2 diabetes mellitus (T2DM) and DKD. Methods. In this case-control study, 75 subjects were included into 3 groups: group (1): 20 patients with T2DM and UACR (urinary albumin creatinine ratio) < 30 mg/gm, group (2): 30 patients with T2DM and ACR ≥ 30 mg/gm, and group (3): 25 healthy controls. Patients were recruited from the outpatient clinic of the Diabetes unit at our institution. Real-Time Quantitative Reverse Transcription PCR was used to assess plasma miRNA-192 expression. Results. Plasma miRNA-192 was significantly higher in T2DM patients with DKD compared to those with normal UAE. Additionally, in patients with T2DM, plasma miRNA-192 was positively correlated with UACR. The ROC curve analysis for miRNA-192 plasma expression in patients with T2DM, revealed that miRNA-192 had a good diagnostic performance (AUC = 0.778) to define T2DM patients with DKD. Conclusion. Plasma expression of miRNA-192 was able to discriminate increased UAE among patients with T2DM; suggesting a promising role for miRNA-192 as a potential biomarker for DKD. |
| Databáze: | OpenAIRE |
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