Poly(α -hydroxy alkanoic acid)s Derived From α -Amino Acids
| Autor: | J. Katzhendler, Naomi Cohen-Arazi, Abraham J. Domb |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Steric effects Polymers and Plastics Chemistry Bioengineering Polymer Ring-opening polymerization Amino acid Biomaterials Polyester chemistry.chemical_compound Monomer Polymerization Yield (chemistry) Polymer chemistry Materials Chemistry Organic chemistry Biotechnology |
| Zdroj: | Macromolecular Bioscience. 13:1689-1699 |
| ISSN: | 1616-5187 |
| DOI: | 10.1002/mabi.201300266 |
| Popis: | Biodegradable polyesters derived from hydrophobic amino acids are synthesized by various techniques, resulting in a wide range of molecular weights. The polymers are prepared via a) direct condensation with p-toluenesulfonic acid (PTSA) as catalyst, b) ring-opening polymerization (ROP) of O-carboxyanhydrides, and c) ROP of cyclic dilactones. The polymers obtained by the first method reach a molecular weight ranging from 1000 to 3000 Da, whereas those formed by the second and third method yield extended molecular weights of 15000-30000 Da. The purity of the monomers as well as their steric bulkiness are key factors affecting the polymerizability of cyclic monomers by ROP. Other parameters such as spatial ring alignment and proximity organization may also play a role. |
| Databáze: | OpenAIRE |
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