Synthesis and properties of branched chemodegradable polymers based on N-vinylpyrrollidone and N-(2-hydroxypropyl)methacrylamide, carriers of biologically active compounds
| Autor: | S. I. Klenin, E. B. Tarabukina, N. V. Nikol'skaya, V. M. Denisov, A. V. Adamov, M. V. Solovskij |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics General Chemical Engineering Radical polymerization General Chemistry Polymer Branching (polymer chemistry) chemistry.chemical_compound Hydrolysis chemistry Polymer chemistry Materials Chemistry Copolymer Methacrylamide Organic chemistry Macromolecule N-(2-Hydroxypropyl) methacrylamide |
| Zdroj: | Designed Monomers and Polymers. 7:63-83 |
| ISSN: | 1568-5551 |
| DOI: | 10.1163/156855504322890043 |
| Popis: | The following polymers were synthesized: water-soluble branched terpolymers: N-vinylpyrrolidone (VP)-crotonic acid (CA)-2-hydroxyethylmethacrylate (HEMA), containing ester and urethane bonds between polymer chains, and homopolymers of N-(2-hydroxypropyl)methacrylamide (HPMA), containing interchain urethane bonds. Hydrodynamic and molecular characteristics of these branched polymers and their hydrolysis rate under the conditions close to physiologic conditions of a living organism (physiologic solution, pH 7.0, temperature 37 °C) were determined. It was established that under these conditions branched VP-CA-HEMA terpolymer (M SD = 67 × 103) and branched poly-HPMA (M SD = 71 × 103) undergo hydrolysis at a relatively high rate, which suggests that they are easily released from the organism. It is shown that these branched chemodegrading polymers can be used as carriers of antibiotics of various classes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|