STAT1: A many-sided transcription factor

Autor:	A. V. Vonarshenko, Valery M. Lipkin, Irina A. Kostanyan
Rok vydání:	2010
Předmět:	biology Growth factor receptor Organic Chemistry biology.protein Cellular homeostasis JAK-STAT signaling pathway STAT1 SOCS3 Signal transduction Biochemistry Transcription factor Cell biology STAT6
Zdroj:	Russian Journal of Bioorganic Chemistry. 36:11-23
ISSN:	1608-330X 1068-1620
Popis:	The cell homeostasis is regulated by numerous signaling proteins. Their common task is to process extracellular signals by triggering cascades of intracellular reactions leading to modulation of down-stream gene activities. One of the important signaling pathways is represented by the STAT family, comprising seven participants. Various STATs operate as the powerful transcription factors delivering cytokine and growth factor signals into nucleus. The first found out and most well studied member of this family is STAT1. This review summarized some modern data on the role of STAT1 in maintening cellular homeostasis, and the special attention is focused on a role of this protein in proliferation, cell growth and apoptosis processes. It is shown, that infringements in functioning of this molecule may contribute to oncogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c7f1d67361c81eab7912beb9b8d125f9 https://doi.org/10.1134/s1068162010010024 Zobrazit plný text záznamu Full text from SpringerLink