Total synthesis of balanol: a potent protein kinase C inhibitor of fungal origin

Autor:	S. M. Fairway, I. Warner, B. W. Sharp, Nigel Vicker, C. P. Adams, Michael B. Hursthouse, Andrew David Morley, C. J. Hardy, D. E. Hibbs
Rok vydání:	1995
Předmět:	chemistry.chemical_compound Fungal metabolite Biochemistry chemistry P70S6 kinase Total synthesis Ring (chemistry) Protein kinase A Protein kinase C Balanol
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :2355
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19950002355
Popis:	The total synthesis of the fungal metabolite balanol, a potent inhibitor of protein kinase C, is described. The synthesis includes a novel synthesis of 3-amino-4-hydroxyazepanes via a directed ring expansion of 3-bromopiperidin-4-ones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c7edc3523ed87631742a7d0c0741e293 https://doi.org/10.1039/p19950002355 Zobrazit plný text záznamu