| Autor: |
Varsha Neelam, Emily L Reeves, Kate R Woodworth, Emily O'Malley Olsen, Megan R Reynolds, Joy Rende, Heather Wingate, Susan E Manning, Paul Romitti, Kristen D Ojo, Kristin Silcox, Jerusha Barton, Evan Mobley, Nicole D Longcore, Ayomide Sokale, Mamie Lush, Camille Delgado-Lopez, Abdoulaye Diedhiou, Deborah Mbotha, Wanda Simon, Bethany Reynolds, Tahani S Hamdan, Suzann Beauregard, Esther M Ellis, Jennifer Y Seo, Amanda Bennett, Sascha Ellington, Aron J Hall, Eduardo Azziz-Baumgartner, Van T Tong, Suzanne M Gilboa |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1670249/v1 |
| Popis: |
Background: People with SARS-CoV-2 infection during pregnancy are at increased risk for adverse pregnancy outcomes, such as preterm birth and stillbirth. Few studies have assessed whether the risk of adverse pregnancy and infant outcomes varies by trimester of infection.Objectives: We describe clinical characteristics (i.e., treatment among pregnant people with moderate to critical illness) and pregnancy and infant outcomes in pregnant people with laboratory-confirmed SARS-CoV-2 infection by trimester of infection.Study Design: The Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET) collects longitudinal data on people with confirmed SARS-CoV-2 infection during pregnancy and their infants. This analysis included people reported to SET-NET with infection in 2020, with known timing of infection and pregnancy outcome. Outcomes are described by trimester of infection. Pregnancy outcomes examined were live birth and pregnancy loss (Results: Among 44,914 people with SARS-CoV-2 infection in pregnancy, 35,200 (78.3%) people with known timing of infection and pregnancy outcome were included. There were 35,574 liveborn infants and 193 pregnancy losses (Conclusions: There were no signals for increased birth defects or SGA among infants in this population relative to national baseline estimates, regardless of timing of infection. However, the prevalence of preterm birth in people with SARS-CoV-2 infection in pregnancy in our analysis was higher relative to national baseline data (10.0-10.2%), particularly among people with third trimester infection. Consequences of COVID-19 during pregnancy, including preterm birth, support recommended COVID-19 prevention strategies, including vaccination for people who are pregnant or may become pregnant. The findings in this report further highlight gaps in COVID-19 treatment for pregnant people. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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