Retracted: Experience of cases with inhaled nitric oxide and therapeutic hypothermia
Autor: | Hiroyuki Sano, Keisuke Kobata, Nanae Yutaka, Tadashi Shinomoto, Makoto Nabetani, Sayaka Shimada, Ran D. Goldman |
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Rok vydání: | 2022 |
Předmět: |
Pediatrics
medicine.medical_specialty business.industry Mortality rate Gross Motor Function Classification System Hypothermia medicine.disease Hypoxic Ischemic Encephalopathy Nitric oxide chemistry.chemical_compound Intraventricular hemorrhage chemistry Pediatrics Perinatology and Child Health medicine Long term outcomes medicine.symptom business Developmental quotient |
Zdroj: | Pediatrics International. 64 |
ISSN: | 1442-200X 1328-8067 |
Popis: | Background Neonates with hypoxic ischemic encephalopathy (HIE) on therapeutic hypothermia (TH) therapy may show persistent pulmonary hypertension of the newborn (PPHN). In Japan, reported mortality rate is lower than in the U.S., possibly due to treatment differences of newborns with moderate to severe HIE and PPHN. The objective of this study was to determine the feasibility and long term outcomes of Inhaled nitric oxide (iNO) and TH therapy in newborns with moderate to severe HIE with PPHN. Methods This was a retrospective review of neonates with moderate to severe HIE that were treated with TH from 2008 to 2017 at a large medical center in Japan. We documented their long term neurological prognosis measuring developmental quotient (DQ) and gross motor function classification system (GMFCS) at 18 months old. Results A total of 37 neonates with moderate to severe HIE underwent TH therapy and six of them were started with iNO therapy for PPHN. iNO with TH was safely started for all six newborns with moderate to severe HIE with PPHN. In two neonates TH was discontinued because of an intraventricular hemorrhage (IVH) and severe hypotension. Neurological outcomes were similar in newborns who were treated with iNO and TH and those who were treated with TH alone. Conclusion These initial findings suggest that monitoring hematologic and cardiovascular status is important with iNO for severe asphyxia infants with PPHN. We have to develop safer and more feasible protocols when we undergo iNO and TH therapy. |
Databáze: | OpenAIRE |
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