Concise synthesis of valuable chiral N -Boc- β -benzyl- β -amino acid via construction of chiral N -Boc-3-benzyl-5-oxoisoxazolidine through cross-metathesis/conjugate addition/oxidation

Autor:	Hao-Ling Gao, Cheng-Sheng Ge, Hong-Tao Jiang
Rok vydání:	2017
Předmět:	chemistry.chemical_classification 010405 organic chemistry Chemistry Enantioselective synthesis General Chemistry 010402 general chemistry Metathesis 01 natural sciences 0104 chemical sciences Amino acid Sitagliptin Phosphate Organocatalysis Organic chemistry Conjugate
Zdroj:	Chinese Chemical Letters. 28:471-475
ISSN:	1001-8417
Popis:	Valuable chiral N-Boc-β-benzyl-β-amino acid was concisely synthesized via construction of chiral N-Boc-3-benzyl-5-oxoisoxazolidine through cross-metathesis/conjugate addition/oxidation. All of the starting materials for the synthesis of chiral N-Boc-β-benzyl-β-amino acid are cheap, and two-step short procedure make it easy for the rapid construction of various chiral β-arylmethyl-β-amino acids and important drugs, such as sitagliptin phosphate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c7e57d785d4f7677b3ff3e0b1604c705 https://doi.org/10.1016/j.cclet.2016.10.005 Zobrazit plný text záznamu Full Text from ScienceDirect