Preclinical assessment of the acute toxicity and anti-inflammatory activity of Wissadula periplocifolia (L.) C. Presl (jangadeira)
| Autor: | Luciana da Silva Nunes Ramalho, Caliandra Maria Bezerra Luna Lima, Andressa Brito Lira, Guilherme Eduardo Nunes Dias, Edla Julinda Ribeiro Coutinho Espinola Guedes, Yanna Carolina Fereira Teles, Reinaldo Nóbrega de Almeida, Josué do Amaral Ramalho, Margareth de Fátima Formiga Melo Diniz, Mateus Feitosa Alves, Gilson EspÃnola Guedes Neto, Maria de Fátima Vanderlei Souza |
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| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
Pharmacology biology business.industry medicine.drug_class medicine.medical_treatment Decreased serum creatinine Pharmaceutical Science biology.organism_classification 01 natural sciences Acute toxicity Anti-inflammatory 0104 chemical sciences 010404 medicinal & biomolecular chemistry Edema Toxicity medicine Alkaline phosphatase Diuretic medicine.symptom business Malvaceae 010606 plant biology & botany |
| Zdroj: | African Journal of Pharmacy and Pharmacology. 10:53-58 |
| ISSN: | 1996-0816 |
| DOI: | 10.5897/ajpp2015.4476 |
| Popis: | Wissadula periplocifolia (L.) C. Presl is a plant of the Malvaceae family that is popularly known as white velvet leaf (“jangadeira” and “malva-malva” in Brazil). Species of this family are used in folk medicine as diuretic, anti-inflammatory and anti-rheumatic agents. This study evaluated the acute toxicity and anti-inflammatory effects of a crude ethanolic extract of W. periplocifolia. Acute toxicity testing revealed reduced food intake and decreased serum creatinine and alkaline phosphatase levels in males, as compared to the control group, suggesting a loss of muscle mass. Assessment of anti-inflammatory activity using a rat paw carrageenan-induced edema model showed that 25 mg/kg of this ethanolic extract significantly reduced edema, although this was not observed at higher doses. These findings indicated that this W. periplocifolia extract was non-toxic and had some anti-inflammatory effects. However, a more comprehensive assessment is necessary to evaluate other possible indicators of toxicity, particularly during chronic administration. Key words: Wissadula periplocifolia, acute toxicity, toxicological test, ethanolic extract , anti-inflammatory activity. |
| Databáze: | OpenAIRE |
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