Plasma neutrophil elastase correlates with pulmonary vascular permeability: A prospective observational study in patients with pneumonia

Autor: Mariko Omura, Kohei Yonezawa, Go Akiyama, Ryoichi Tosa, Takashi Tagami, Shigeki Kushimoto, Hiroyuki Yokota, H Hirama
Rok vydání: 2011
Předmět:
Zdroj: Respirology. 16:953-958
ISSN: 1323-7799
DOI: 10.1111/j.1440-1843.2011.01997.x
Popis: Background and objective: Little is known about plasma neutrophil elastase (PNE) levels in patients with community-acquired pneumonia (CAP) requiring treatment in the intensive care unit (ICU) or high care unit (HCU). In addition, the influence of PNE on pulmonary vascular permeability in a clinical setting has not been investigated. The aims of this study were (i) to investigate PNE levels in patients with CAP and (ii) to explore the relationship between PNE and pulmonary vascular permeability. Methods: Fourteen consecutive CAP patients who were admitted to the HCU (n = 8) or ICU (n = 6) were prospectively investigated over a 6-month period. A group of eight patients with hydrostatic pulmonary oedema without CAP served as a control group (CG). PNE levels were measured at regular intervals. The pulmonary vascular permeability index (PVPI) was monitored in all ICU and CG patients, using the PiCCO system. Results: PNE levels were higher in the CAP patients (132 (84–261) ng/mL) than in the CG patients (77 (64–107) ng/mL) (P = 0.04), and were highest in the ICU patients (186 (75–466) ng/mL). The PVPI was higher in the ICU patients (2.85 (1.90–4.00)) than in the CG patients (1.15 (0.75–2.35)) (P = 0.02). PNE levels correlated with PVPI in the ICU patients (r = 0.81, P
Databáze: OpenAIRE
Externí odkaz: