The Etiology of Viral Lower Respiratory Tract Infections at a Tertiary Hospital in Jordan over Five Years
| Autor: | Mona Freihat, Maisa Mansour, Hanan Khalil, Azmi Mahafzah, Nathir M. Obeidat, Rasha Bsisu, Isam Bsisu, Mousa Amer, Zaina Obeidat, Randa I. Farah, Nidaa A. Ababneh, Mohammed Obeidat, Mai Altous |
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| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
Pharmacology medicine.medical_specialty Respiratory tract infections business.industry viruses Mortality rate medicine.disease medicine.disease_cause Virus respiratory tract diseases Lower respiratory tract infection Internal medicine Pandemic medicine Etiology Pharmacology (medical) Rhinovirus business Cause of death |
| Zdroj: | The International Arabic Journal of Antimicrobial Agents. 9 |
| ISSN: | 2174-9094 |
| DOI: | 10.3823/831 |
| Popis: | Background Lower respiratory tract infection (LRTI) is the most common condition treated in primary care and is considered the third leading cause of death worldwide. The objective of our study is to determine the etiological agents that cause viral LRTI in Jordan, aiming to help physicians to choose the appropriate treatment strategy. Materials and Methods We conducted a retrospective study on patients who were admitted with the diagnosis of LRTI between January, 2011 and January, 2016. We used Fast-track Diagnostics (FTD)® Respiratory 21 Kit (Fast-track Diagnostics, Luxembourg) real-time PCR to determine the viral etiology of LRTI, and we investigated pandemic H1N1 2009 swine flu virus using rapid test PCR. Results This study involved 495 patients with a mean age of 57.79 ± 18.43 years. The causative agents were identified in 157 patients out of 495 patients (31.7%). FTD real-time PCR was done for 170 patients, and the test was positive for seasonal Influenza A virus in 7.1% of patients, influenza B in 4.1%, RSV in 4.7%, metapneumovirus in 4.1%, adenovirus in 4.1%, corona 229E/NL63 in 4.1%, parainfluenza virus in 7.6%, and rhinovirus in 3.5%. The percent of cases who were positive for pandemic H1N1 2009 swine flu virus was 4.2%. The rate of ICU admission was 16.8%, and the mortality rate of LRTI was as low as 3.64%. Conclusions Viral LRTI is more common in winter season in Jordan, especially in January. Remarkably, Influenza A and Parainfluenza viruses were the main viral causative agents for LRTI in our study. |
| Databáze: | OpenAIRE |
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