Selective and Effective Cytotoxicity of Folic Acidconjugated Cholesteryl Pullulan Hydrogel Nanoparticles Complexed with Doxorubicin inΓIn Vitro and ΓIn Vivo Studies
| Autor: | Masaaki Hidaka, Kazutoshi Ushio, Junzo Sunamoto, Takashi Kanematsu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Polymers and Plastics
Chemistry 0206 medical engineering Bioengineering 02 engineering and technology Pharmacology 021001 nanoscience & nanotechnology 020601 biomedical engineering In vitro Biomaterials Targeted drug delivery In vivo Folate receptor Cancer cell Drug delivery Materials Chemistry medicine Doxorubicin 0210 nano-technology Cytotoxicity medicine.drug |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 21:591-602 |
| ISSN: | 1530-8030 0883-9115 |
| DOI: | 10.1177/0883911506069871 |
| Popis: | We previously reported that cholesteryl pullulan (CHP) derivatives were effective carriers drug delivery systems in targeting cancer cells. We have now synthesized folic acid-conjugated CHP hydrogel nanoparticles (FACHP). FA-CHP complexed with the anticancer drug doxorubicin (DOX) show a higher cytotoxicity than CHP complexed with DOX in in vitro studies. The expression of a folate receptor (FR) is elevated in many cancers; in this case, confocal image analysis revealed that FA-CHP complexed with DOX exhibited greater cellular uptake than CHP complexed with DOX in human epidermal carcinoma (KB) cells over-expressing surface FR. In vivo studies showed that the increase of tumor volume in a nude mice xenograft model was significantly suppressed. Accordingly, FA-CHP may be an effective vehicle for the delivery of anticancer drugs and has a potential application in the treatment of overexpressing FR solid tumor cells. |
| Databáze: | OpenAIRE |
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