Solvent-controlled, regio-switchable formation of 3-/5-arylaminopyrazole isomer in cyclocondensation of β-aminoenones with hydrazides: intermolecular hydrogen bonding plays a role

Autor: Xihe Bi, Zikun Wang, Peiqiu Liao, Dewen Dong, Xiaoqing Xin, Dexuan Xiang, Guichun Fang
Rok vydání: 2013
Předmět:
Zdroj: RSC Adv.. 3:386-389
ISSN: 2046-2069
DOI: 10.1039/c2ra22647b
Popis: An unprecedented solvent-controlled, regio-switchable Knorr-type reaction for the synthesis of pyrazoles has been realized in the cyclocondensation of β-aminoenones with hydrazides. Single regioisomer of 3- or 5-arylaminopyrazole can be obtained simply by changing the reaction solvent. Using hydrazine hydrate, only 3-arylaminopyrazoles were produced.
Databáze: OpenAIRE