Solvent-controlled, regio-switchable formation of 3-/5-arylaminopyrazole isomer in cyclocondensation of β-aminoenones with hydrazides: intermolecular hydrogen bonding plays a role
Autor: | Xihe Bi, Zikun Wang, Peiqiu Liao, Dewen Dong, Xiaoqing Xin, Dexuan Xiang, Guichun Fang |
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Rok vydání: | 2013 |
Předmět: | |
Zdroj: | RSC Adv.. 3:386-389 |
ISSN: | 2046-2069 |
DOI: | 10.1039/c2ra22647b |
Popis: | An unprecedented solvent-controlled, regio-switchable Knorr-type reaction for the synthesis of pyrazoles has been realized in the cyclocondensation of β-aminoenones with hydrazides. Single regioisomer of 3- or 5-arylaminopyrazole can be obtained simply by changing the reaction solvent. Using hydrazine hydrate, only 3-arylaminopyrazoles were produced. |
Databáze: | OpenAIRE |
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