A direct conversion of carboxylic acids to methylthiomethyl esters using a microwave-assisted pummerer rearrangement with dimethylsulfoxide

Autor:	Madhuri Manpadi, Russell Spatney, Allison McCarthy, Brian J. Myers, Jake R. Zimmerman
Rok vydání:	2012
Předmět:	chemistry.chemical_classification chemistry Carboxylic acid Pummerer rearrangement Organic Chemistry Drug Discovery Extraction (chemistry) Organic chemistry Protecting group Biochemistry Long chain Microwave assisted Alkyl
Zdroj:	Tetrahedron Letters. 53:4782-4784
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.06.136
Popis:	A simple microwave-assisted method for the conversion of carboxylic acids to MTM esters is presented. This new process allows for rapid introduction of an MTM ester protecting group to a variety of carboxylic acids including alkyl, electron-rich aromatic, and long chain unsaturated carboxylic acids. The products isolated from this reaction are very pure after a simple extraction, which eliminates the need for further purification. The reaction has also been carried out on 1.50 g without deterioration of product yields or purity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c7b11965604c221f67dfeb5ad6ca55ac https://doi.org/10.1016/j.tetlet.2012.06.136 Zobrazit plný text záznamu Full Text from ScienceDirect