A case of IgG4-related lung disease complicated by asymptomatic chronic Epstein-Barr virus infection
| Autor: | Yasuaki Kotetsu, Shohei Takata, Kan Okabayashi, Takaomi Koga, Keiko Takebe-Akazawa, Satoshi Ikegame |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Lung Mediastinal lymphadenopathy business.industry medicine.disease Asymptomatic 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030228 respiratory system Immunology and Allergy Medicine IgG4-related disease Lymph medicine.symptom business Asymptomatic carrier Epstein–Barr virus infection Lymph node Genetics (clinical) |
| Zdroj: | The Clinical Respiratory Journal. 11:1012-1017 |
| ISSN: | 1752-6981 |
| Popis: | Introduction IgG4-related disease is characterized by IgG4-positive plasmacyte infiltration into various organs, but its etiology is not unknown. Objectives To elucidate the etiology of IgG4-related disease. Methods We experienced an interesting case of IgG4-related lung disease complicated by chronic EB virus infection. Results A 70-year-old male visited our hospital due to failure of pneumonia treatment. Chest computed tomography (CT) showed consolidation in the right middle field and slight mediastinal lymphadenopathy in the subcarinal region. Lung consolidation improved with antibiotics; subcarinal lymphadenopathy progressed after 4 months. Malignant lymphoma was suspected given elevated sIL2-R levels (1862 U/mL). Patchy ground glass opacities appeared in the bilateral lung field just before surgical biopsy. He was diagnosed with IgG4-related lung disease after inspection of a pathological specimen obtained from the right upper lung and right hilar lymph node. EB virus-infected cells were also detected in the lymph node. Blood examination revealed EB virus viremia, but the patient did not present with symptoms or organ involvement. This led to a diagnosis of asymptomatic chronic EB virus infection. Conclusion Recent studies have suggested an association between EB virus infection and IgG4-related diseases in the pathological exploration of surgically resected lymph nodes. Our case is the first case of IgG4-related lung disease in which EB virus infection was both pathologically and clinically proved. The present case is of particular interest in view of this newly reported association, and may serve as a fundamental report for future studies connecting EB virus infection with IgG4-related diseases. |
| Databáze: | OpenAIRE |
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