Epoxyquinophomopsins A and B from endophytic fungus Phomopsis sp. and their activity against tyrosine kinase

Autor:	Suzany D Ellita, Yana M. Syah, Euis H. Hakim, Hayato Ishikawa, Lia D. Juliawaty, Elvira Hermawati
Rok vydání:	2020
Předmět:	Non-receptor tyrosine kinase food.ingredient biology Chemistry Receptor tyrosine kinase Quinone Morus cathayana food Biochemistry biology.protein Molecular Medicine Kinase activity Receptor Tyrosine kinase Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Journal of Natural Medicines. 75:217-222
ISSN:	1861-0293 1340-3443
Popis:	Two new quinone derivatives, epoxyquinophomopsins A (1) and B (2), were purified from the EtOAc extract of endophytic fungus Phomopsis sp isolated from Morus cathayana. The structures of both compounds were determined based on 1D and 2D NMR and mass spectral data, as well as by x-ray diffraction analysis for 1. Compounds 1 and 2 were screened against eight receptor- (RTKs) and eight non-receptor tyrosine kinases (nRTKs). Both compounds showed strong inhibitory properties against Bruton's Tyrosine Kinase (nRTK) with their kinase activity were 19% and 20%, respectively. Only compound 1 that showed strong inhibitory properties against RTKs EGFR and HER-4 with its kinase activity were 16 and 15%, respectively. Thus, both compounds have potential as tyrosine kinase inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c7a07f57e3ad57c2855a5c6128ec9706 https://doi.org/10.1007/s11418-020-01454-1 Zobrazit plný text záznamu Full text from SpringerLink