Synthesis, Anti-inflammatory Activity and in silico Studies of Some Novel Morpholine Based Carboxamides

Autor:	Vasantha Kumar, Swamy Sreenivasa, Premanand M. Honavar, P. Nikhil, Naveen Kumar, P. Vishwanatha, Boja Poojary, B. Shivarama Holla
Rok vydání:	2020
Předmět:	010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Biochemistry 010405 organic chemistry medicine.drug_class Morpholine In silico medicine General Chemistry 01 natural sciences Anti-inflammatory 0104 chemical sciences
Zdroj:	Asian Journal of Chemistry. 32:901-906
ISSN:	0975-427X 0970-7077
Popis:	Two series of carboxamides were synthesized from 3-fluoro-4-morpholinoaniline and different substituted aromatic/heterocyclic carboxylic acids. All the compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral data. The newly synthesized amide derivatives were screened for anti-inflammatory activity by following carrageenan induced rat paw edema method. Among the compounds screened, compound 6e was found to be highly potent. Molecular docking interaction of active compounds revealed that effective binding was observed in the pocket of COX-I and COX-II proteins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c79ca529da55d35e84b7bdd205293eb9 https://doi.org/10.14233/ajchem.2020.22488 Zobrazit plný text záznamu