ChemInform Abstract: 1,2,5,6-Tetrahydropyridine Oxime Ethers Incorporating Electron Withdrawing Groups are Potent and Selective Muscarinic Agonists

Autor:	Frank Brown, Steven Mark Bromidge, Graham J. Riley, Emma J. Collings, Loudon Julia Mary, Barry Sidney Orlek, Richard E. Faulkner, Frederick Cassidy, Michael S. G. Clark, Steven Dabbs
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Nitrile Chemistry Muscarinic acetylcholine receptor Polar effect General Medicine Receptor Selectivity Oxime Ring (chemistry) Medicinal chemistry
Zdroj:	ChemInform. 25
ISSN:	0931-7597
Popis:	The combination of N-methoxy imidoyl halide and nitrile moieties with the 1,2,5,6-tetrahydropyridine ring system afforded a novel series of potent muscarinic agonists. Members of this class, exemplified by the imidoyl nitriles 2c and 3c , show favourable central selectivity. The incorporation of fluoroacetyl oxime ethers gave compounds with weak affinity for muscarmic receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c7939ce7c88bc532d4d5b011567f0492 https://doi.org/10.1002/chin.199434167 Zobrazit plný text záznamu Plný text