| Autor: |
Garam Kim, M.-Marsel Mesulam, Melanie Peterson, Eileen H. Bigio, Tamar Gefen, Emily Rogalski, Changiz Geula, Steven Papastefan, Sandra Weintraub |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Neurobiology of Aging. 35:718 |
| ISSN: |
0197-4580 |
| DOI: |
10.1016/j.neurobiolaging.2013.10.048 |
| Popis: |
s / Neurobiology of Aging 35 (2014) 715–724 718 formation. Stereological methods were used for counting double stained and single stained BFCN. Results. Double staining for CB and thioflavin-S or PHF-1 revealed that the overwhelming majority of pre-tangles and tangles in both normal (n1⁄44) and AD (n1⁄44) were found in BFCN that lacked CB immunoreactivity. The ratio of double stained cells as a function of total CB-positive or total thioflavin-s / PHF-1-positive cells was extremely small (0.7 – 7.5 %). Comparing immunoreactivity for the antibodies that appear at different stages of tangles formation, we found that the early-stage antibody TOC-1 was present in a significantly larger number of CB-positive BFCN when compared with the late-stage antibody MN422 (p 0.05) or neuronal size (p>0.05) among the three groups across the cingulate. However, significantly lower NFT density was detected in anterior cingulate regions in SuperAgers compared to NC and aMCI groups (p 0.05). Conclusions. Based on these preliminary results, total neuronal size and density do not seem to contribute significantly to cortical integrity of the cingulate in SuperAgers, while the absence of Alzheimer’s disease pathology, particularly NFT, may represent a putative neurobiological substrate. Further quantification is needed to evaluate the functional circuitry of the cingulate cortex and its many distinctive histopathologic elements in larger groups of post-mortem specimens in order to identify comprehensively the biological basis of superior cognitive aging. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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