Fabrication of Porous α-TCP/Gellan Gum Scaffold for Bone Tissue Engineering
| Autor: | Ill Yong Kim, Koichi Kikuta, Jian Wen, Chikara Ohtsuki |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Scaffold
Materials science Biomedical Engineering Sintering Bioengineering 02 engineering and technology engineering.material Polysaccharide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Coating Tissue engineering General Materials Science 030212 general & internal medicine Composite material Porosity chemistry.chemical_classification General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Gellan gum Compressive strength chemistry engineering 0210 nano-technology |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 16:3077-3083 |
| ISSN: | 1533-4899 1533-4880 |
| DOI: | 10.1166/jnn.2016.12463 |
| Popis: | α-tricalcium phosphate (α-TCP, α-Ca3(PO4)2) receives great attention for bone repairing due to its biodegradability and capability of transformation to human bone's main inorganic components, hydroxyapatite (HAp). α-TCP porous scaffold is easily procurable by sintering of the low-temperature polymorph of TCP, β-TCR Still, porous body of α-TCP is too brittle to being handled and shaped, limiting its clinical application as implant materials. To improve mechanical properties of α-TCP porous scaffold, the present study focused on coating of a type of polysaccharides on α-TCP scaffolds. Gellan gum was chosen as the polysaccharide for coating because of its biodegradability as well as the potential acting as substrate for HAp deposition during hydration of α-TCP after exposure to body fluid. After coating of gellan gum on α-TCP scaffolds with porosity of 75 vol%, the compressive strength increased from 0.45 MPa to around 2.00 MPa. Among the coated scaffold, the maximum compressive strength, 3.97 MPa, was obtained on the scaffold with porosity of 63 vol%. Improvement of mechanical properties of α-TCP/gellan gum composites was achieved to show easy handling performance for a bone substitute for tissue repairing. The dissolving rate of the coated scaffolds was also controlled by adjusting the concentration of GG solutions. |
| Databáze: | OpenAIRE |
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