P2‐067: IMMUNOGLOBULIN‐GENERAL AMYLOID INTERACTION MOTIF (IG‐GAIM) MOLECULES TARGET BETA AMYLOID AND NEUROFIBRILLARY TANGLES IN VITRO AND IN VIVO
| Autor: | Jonathan M. Levenson, Valerie Cullen, Eliezer Masliah, Michal Lulu, Myra Gartner, Richard Fisher, Haim Tsubery, Elliott J. Mufson, Jason Wright, Rajaraman Krishnan, Sally Schroeter, Kimberley Gannon, Beka Solomon, Sharon Gilead, Ming Proschitsky, Edward Rockenstein, Jenna C. Carroll, Muhammad Nadeem, Jonathon Waltho, Peter Davis, David G. Myszka, Eva Asp |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
biology Amyloid Epidemiology Chemistry Health Policy Lymphocyte Immunosenescence Biochemistry of Alzheimer's disease Psychiatry and Mental health Cellular and Molecular Neuroscience Lymphocyte chemotaxis Endocrinology medicine.anatomical_structure Developmental Neuroscience Internal medicine medicine Amyloid precursor protein biology.protein Neurology (clinical) Senile plaques Geriatrics and Gerontology Lymphoproliferative response |
| Zdroj: | Alzheimer's & Dementia. 10 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2014.05.741 |
| Popis: | antioxidants (GSH and catalase activities) were assessed. Furthermore, the Kaplan-Meier test was used to calculate the average life expectancy. Results: 3xTgAD mice showed lower values of macrophage functions, lymphocyte chemotaxis, NK cells proportion and activity, and GSH from the onset of illness, whereas lymphoproliferative response was exacerbated. Moreover, GSSG/GSH ratio and xanthine oxidase activity are higher in these animals during the establishment of the disease. The 3xTgAD mice showed a shorter lifespan (p |
| Databáze: | OpenAIRE |
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