| Autor: |
Young-Eun Lee, Moon Kyung Kang, Won Hong Woo, Yeun Ja Mun |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Korean Journal of Oriental Physiology & Pathology. 28 |
| ISSN: |
1738-7698 |
| DOI: |
10.15188/kjopp.2014.10.28.5.506 |
| Popis: |
Commelina communis Ledeb is a widely used medication for the treatment of antidiabetic, antioxidant and hypoglycemic agent in Korea. Alpha-melanocyte stimulating hormone (α-MSH) is a major factor to stimulate melanin synthesis in the skin. The purposes of this study was to investigate the inhibitory effects of extract from Commelina communis Ledeb (ECC) on α-MSH-stimulated melanogenesis in B16F10 cells. ECC suppressed melanin synthesis and intracellular tyrosinase activity in B16F10 cells or α-MSH-induced B16F10 cells in a dose dependent manner. In study on the melanogenic protein expressions, it had especially influence on expressions of tyrosinase and tyrosinase-related protein (TRP-1). Tyrosinase and TRP-1 expressions were gradually decreased in a dose-dependent. Additionally, the extract also decreased the α-MSH-induced over-expression of tyrosinase and TRP-1. This results show that the anti-melanogenic activity of ECC is correlated with the suppression of tyrosinase and TRP-1 protein expressions in B16F10 cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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