The changes in the electric impedance during activity and the effect of alkaloids and polarization upon the bioelectric processes in the myelinated nerve fibre

Autor: Kanji Mizuguchi, Ichiji Tasaki
Rok vydání: 1949
Předmět:
Zdroj: Biochimica et Biophysica Acta. 3:484-493
ISSN: 0006-3002
DOI: 10.1016/0006-3002(49)90120-1
Popis: 1. 1. High frequency alternating current impedance measurements have been made, during rest and activity, on isolated single nerve fibres of the toad. 2. 2. During activity there is a decrease in the impedance of the plasma membrane at the nodes of Ranvier . The time course of the impedance loss is the same as that of the “action electromotive force” set up at the plasma membrane. 3. 3. The impedance change and the action current production are two different expressions of one and the same bioelectric process which occurs at the plasma membrane. 4. 4. Cocaine and many other alkaloids reduce the magnitude and duration of the bioelectric response. Sinomenine and several other alkaloids prolong the duration of the response in a very characteristic manner. Veratrine retards complete recovery from a previous activity. 5. 5. Catelectrotonus depresses and anelectrotonous enhances the bioelectric process.
Databáze: OpenAIRE