Transmission of Coxiella burnetii by ingestion in mice
| Autor: | Halie K. Miller, Rachael A. Priestley, Gilbert J. Kersh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Epidemiology Transmission (medicine) 030106 microbiology Q fever Biology bacterial infections and mycoses Coxiella burnetii biology.organism_classification medicine.disease Microbiology Serology Persistence (computer science) 03 medical and health sciences 030104 developmental biology Infectious Diseases medicine.anatomical_structure Immune system medicine bacteria Mesenteric lymph nodes Ingestion |
| Zdroj: | Epidemiology and Infection. 148 |
| ISSN: | 1469-4409 0950-2688 |
| Popis: | Coxiella burnetii, the causative agent of Q fever, is widely present in dairy products around the world. It has been isolated from unpasteurised milk and cheese and can survive for extended periods of time under typical storage conditions for these products. Although consumption of contaminated dairy products has been suggested as a potential route for transmission, it remains controversial. Given the high prevalence of C. burnetii in dairy products, we sought to examine the feasibility of transmitting the major sequence types (ST16, ST8 and ST20) of C. burnetii circulating in the United States. We delivered three strains of C. burnetii, comprising each sequence type, directly into the stomachs of immunocompetent BALB/c mice via oral gavage (OG) and assessed them for clinical symptoms, serological response and bacterial dissemination. We found that mice receiving C. burnetii by OG had notable splenomegaly only after infection with ST16. A robust immune response and persistence in the stomach and mesenteric lymph nodes were observed in mice receiving ST16 and ST20 by OG, and dissemination of C. burnetii to peripheral tissues was observed in all OG infected mice. These findings support the oral route as a mode of transmission for C. burnetii. |
| Databáze: | OpenAIRE |
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